Characterisation of the proximal regulatory domain of the Echinococcus granulosus homeodomain-containing gene EgHbx1
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Updated: Oct 17, 2026

Transient Transduction of the Strobilated Forms of Echinococcus granulosus
Published on: September 16, 2022
P Esperón1, N Gorfinkiel, B Garat
1Sección Bioquímica, Facultad de Ciencias, Iguá 4225, Montevideo, Uruguay.
Abstract:
In an attempt to understand the molecular basis of the development of Echinococcus granulosus, we have previously isolated several homeobox-containing genes (EgHbx1-5). Here we report the characterisation of the EgHbx1 proximal regulatory domain. EgHbx1 codes for an amino acid sequence presenting 90% identity at the homeodomain level with the Drosophila melanogaster NK1-S59 transcription factor. The proximal regulatory domain sequence and the transcription start site were determined. Electrophoretic mobility shift assays using nuclear extracts from protoscoleces revealed the presence of specific DNA-protein complexes. These results constitute a hint and provide new tools to decipher regulatory cascades during E. granulosus development.
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