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Differential neurotrophin levels in cerebrospinal fluid and their changes during development in newborn rat
1Department of Obstetrics and Gynaecology, Miyazaki Medical College, 5200 Kihara, Kiyotake-Cho, Miyazaki, Japan.
Neuroscience Letters
|February 17, 2000
Abstract:
Cerebrospinal fluid concentration of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) was measured in normal developing rat from birth to postnatal day (PND) 21 by enzyme-linked immunosorbent assay. NGF levels were significantly higher than those of BDNF and NT-3 from PND 1-21. NGF levels decreased from PND 1-3 to PND 9. At PND 15 and 17, NGF levels peaked a second time and rapidly decreased to PND 21. BDNF peaked at PND 13-15, while NT-3 levels peaked at PND 7-9. Each of the three neurotrophins has its own characteristic pattern in changes in cerebrospinal fluid levels.