Return of granulocyte transfusions

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Image-based Flow Cytometry Technique to Evaluate Changes in Granulocyte Function In Vitro
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D C Dale1, W C Liles

  • 1Department of Medicine, University of Washington, Seattle 98195-6422, USA.

Current Opinion in Pediatrics
|February 17, 2000
PubMed

Recently, several groups have begun to administer granulocyte colony-stimulating factor (G-CSF), a hematopoietic growth factor, with or without dexamethasone to mobilize peripheral blood neutrophils. Granulocyte colony-stimulating factor (600 microg subcutaneously) and dexamethasone (8 mg orally) given 12 hours before standard leukapheresis routinely results in the collection of approximately 80 x 10(9) granulocytes. This number of cells is sufficient to increase the neutrophil count of a severely neutropenic patient to normal and restore the recipients' ability to develop a neutrophil response in tissues. Several trials are ongoing to establish the clinical benefit of this new approach to supportive care for neutropenic patients.

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