[Tissue adhesion and local haemostasis using fibrinogen, thrombin and clotting factor xiii. (experimental...

A report is given on experimental investigations and clinical experience in the use of a biological adhesive system. This system consists of highly-concentrated native fibrinogen, thrombin and clotting factor XIII. Experimental tissue adhesion was successfully performed in numerous experiments and with various organs. Local haemostasis was obtained even in cases when other methods failed by sealing off bleeding surfaces with a fibrin layer. The satisfactory results obtained in these experimental investigations were confirmed by the excellent outcome of a clinical trial. Fibrin represents a biological system which is completely absorbable, contrary to the commonly-used synthetic adhesives. Further advantages are its highly adhesive properties, elasticity of consistency and good tissue compatibility.