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Updated: Aug 18, 2026

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
Published on: April 28, 2013
[Functional scintigraphy of the kidneys with 99mtc-pertechnetate (author's transl)]
Abstract:
Sequential Scintigraphy or Functional Scintigraphy of the kidneys after intravenous injection of 99mTc-pertechnetate using a Gamma-camera yields important information about total and regional blood flow by observation of the radioactive bolus passage through the kidneys. Differential diagnosis between vascular (tumors) and non-vascular (cysts, infarcts, scar tissue) parenchymatous lesions can be established with high accuracy. Simultaneous registration of time-activity histograms for the individual kidney as a region of interest (Functional Scintigraphy) provides, furthermore, the possibility of assessing circulatory function of the investigated organ. The assessment of such time-activity histograms provides an additional accuracy in the evaluation of the Sequential scintigrams. The parameters of these time-activity histograms are discussed in detail. Standardized conditions of injection procedure are a basic requirement. An evaluation of the fraction of cardiac output supplying the individual kidney in comparison to the contralateral side is possible. One of the advantages of the method is the simplicity of its application. It is without discomfort for the patient and without risk apart from the inherent very low radiation dose. It is particulary suited for follow-up studies.
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