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Updated: Aug 17, 2026

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
Published on: June 11, 2019
The spleen: anatomy and anatomical function
1Department of Pathology, Joan and Sanford I. Weill Medical College of Cornell University and New York Presbyterian Hospital, New York 10021, USA.
Abstract:
In this review, our knowledge concerning the structure and function of the spleen is summarized. The unique architecture of the spleen allows for interactions between the circulatory, reticuloendothelial, and immune systems. Based on these interactions in conjunction with its microanatomy, the spleen is able to maintain the integrity of the blood and respond to circulating antigens. However, this can be a double-edged sword in the case of patients suffering from autoimmune diseases such as immune thrombocytopenic purpura since the spleen can be the site of both antibody production and circulating cell destruction.
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