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Treatment of infant colic with amino acid-based infant formula: a preliminary study

D C Estep1, A Kulczycki

  • 1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Acta Paediatrica (Oslo, Norway : 1992)
|February 17, 2000
PubMed

Insights

An amino acid-based formula, Neocate, effectively reduced crying and fussing in infants with colic. This study suggests bovine IgG may play a role in infant colic symptoms.

Area of Science:

  • Pediatrics
  • Neonatology
  • Gastroenterology

Background:

  • Infant colic is a common condition causing excessive crying in newborns.
  • Current management strategies for infant colic are limited.

Purpose of the Study:

  • To evaluate the tolerance and efficacy of Neocate, an amino acid-based formula, in infants with colic.
  • To investigate the potential role of bovine IgG in infant colic.

Main Methods:

  • A preliminary study involving six infants diagnosed with colic (3-7 weeks old).
  • Infants were fed their usual formula, then exclusively Neocate, with symptoms tracked using behavior diaries.
  • Oral bovine IgG challenges were administered to assess its impact on crying and fussing.

Main Results:

  • All infants tolerated Neocate well, with significant improvement in colic symptoms within 1-2 days.
  • Average crying and fussing time decreased by 45% (1.0-5.2 hours daily).
  • Bovine IgG challenges led to increased crying and fussing, suggesting its potential etiological role.

Conclusions:

  • Neocate is a well-tolerated and effective option for managing infant colic.
  • Bovine IgG may be an important factor in the development or exacerbation of infant colic.

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