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Related Experiment Videos

Development of matrix-based theophylline sustained-release microtablets.

H Rey1, K G Wagner, P Wehrlé

  • 1Laboratoire de Pharmacotechnie, Faculté de Pharmacie de Strasbourg 74, Illkirch, France.

Drug Development and Industrial Pharmacy
|April 1, 2000
PubMed
Summary
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High theophylline microtablets were developed using Eudragit RS PO. Formulation factors like plasticizer and magnesium stearate content influenced drug release, achieving sustained-release profiles meeting USP standards.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Developing sustained-release drug delivery systems is crucial for therapeutic efficacy.
  • Microtablets offer advantages in dose flexibility and patient compliance.

Purpose of the Study:

  • To formulate and characterize high theophylline content microtablets using Eudragit RS PO.
  • To investigate the impact of formulation variables on theophylline release kinetics.
  • To assess the stability of the developed microtablets.

Main Methods:

  • Microtablets were produced via rotary tablet press with varying theophylline content (60-80%).
  • Compaction pressure, plasticizer (triethyl citrate), and magnesium stearate concentrations were optimized.
  • Dissolution profiles were determined using USP standards over 8 hours.

Related Experiment Videos

  • Storage stability was evaluated at room temperature and elevated temperature (50°C).

    • Main Results:

    • Compaction pressure did not significantly affect theophylline release.
    • Triethyl citrate improved microtablet physical properties.
    • Theophylline release correlated with the surface area/tablet weight ratio.
    • Magnesium stearate addition effectively reduced dissolution rates, creating hydrophobic formulations.
    • Formulations met USP 23 sustained-release requirements for theophylline.
    • Microtablets exhibited good storage stability.

    Conclusions:

    • Eudragit RS PO is suitable for formulating high theophylline content microtablets with tunable release profiles.
    • Magnesium stearate is an effective agent for controlling theophylline dissolution rate.
    • The developed microtablets demonstrate potential as a stable, sustained-release theophylline dosage form.