Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The aortic valve blood supply.

K L Weind1, C G Ellis, D R Boughner

  • 1The Heart Valve Laboratory, Robarts Research Institute, London, Ontario, Canada.

The Journal of Heart Valve Disease
|March 4, 2000
PubMed
Summary

Porcine aortic valves possess a vascular network, indicating their metabolic needs exceed surface diffusion. This intrinsic circulation is crucial for understanding bioprosthetic valve durability and future tissue-engineered valve development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acceptability of high-resolution anoscopy for anal cancer screening in HIV-infected patients.

HIV medicine·2018
Same author

Role of erythrocyte-released ATP in the regulation of microvascular oxygen supply in skeletal muscle.

Acta physiologica (Oxford, England)·2015
Same author

Mass Transfer in a Rigid Tube With Pulsatile Flow and Constant Wall Concentration.

Journal of fluids engineering·2011
Same author

Influence of tissue metabolism and capillary oxygen supply on arteriolar oxygen transport: a computational model.

Mathematical biosciences·2011
Same author

Optimizing the tensile properties of polyvinyl alcohol hydrogel for the construction of a bioprosthetic heart valve stent.

Journal of biomedical materials research·2002
Same author

A precise radiographic technique for the measurement of dimensional changes in heart valve biomaterials following fixation.

Journal of biomechanics·2002

Area of Science:

  • Cardiovascular Research
  • Vascular Biology
  • Biomaterials Science

Background:

  • Normal heart valves are metabolically active, but oxygen supply routes are not fully understood.
  • Diffusion from the valve surface is the presumed oxygen source, but the aortic valve's vascular bed remains unclear.

Purpose of the Study:

  • To investigate the presence, distribution, and significance of the aortic valve's vascular bed.
  • To clarify oxygen delivery mechanisms in normal aortic valves.

Main Methods:

  • Seventeen porcine hearts were used, with coronary circulation rinsed and filled with a contrast agent.
  • Aortic valve cusps were dissected, fixed, and microscopically examined.
  • Vascular distribution was evaluated using digital image reconstruction and analysis.

Main Results:

  • 71% of porcine aortic valve cusps examined contained visible vessels.
  • Vessels were primarily located in the basal third of cusps, extending from commissures.
  • A statistically significant difference in vascularization was observed between basal and other regions (p<0.001).

Conclusions:

  • The identified vasculature suggests aortic valve metabolic activity surpasses surface diffusion.
  • The absence of functioning vessels may contribute to cryopreserved and bioprosthetic valve failures.
  • Understanding intrinsic circulation is vital for developing advanced tissue-engineered valves.

Related Experiment Videos