Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Normative data for iliac bone histomorphometry in growing children.

F H Glorieux1, R Travers, A Taylor

  • 1Department of Surgery, McGill University, Montréal, Québec, Canada. glorieux@shriners.mcgill.ca

Bone
|March 25, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs.

American journal of physiology. Cell physiology·2005
Same author

Life history of osteocytes: relationship to bone age, bone remodeling, and bone fragility.

Journal of musculoskeletal & neuronal interactions·2005
Same author

What is the normal rate of bone remodeling?

Bone·2004
Same author

The mineralization index--a new approach to the histomorphometric appraisal of osteomalacia.

Bone·2004
Same author

The attainment of peak bone mass: what is the relationship between muscle growth and bone growth?

Bone·2004
Same author

Large calcium fluxes that are not related to remodeling exist.

Bone·2003
Same journal

Diagnosis and management of X-linked hypophosphatemia in dental practice: A scoping review.

Bone·2026
Same journal

Baseline β-CTX and BMI predict suitability for deferred zoledronic acid redosing beyond 12 months in postmenopausal Indian women with osteoporosis.

Bone·2026
Same journal

Bone density-based maturation of the midpalatal suture in children aged 8-15 years.

Bone·2026
Same journal

Disrupted phosphate metabolism and SIBLING/ASARM peptide accumulation underlie impaired bone mineralization in klotho-deficient (kl/kl) mice.

Bone·2026
Same journal

Linking genetic variants to bone microstructure: Histological signatures of osteogenesis imperfecta subtypes.

Bone·2026
Same journal

The impact of alcohol consumption on bone mineral density: Insights from cross-sectional and Mendelian randomization studies.

Bone·2026
See all related articles

This study provides crucial pediatric bone histomorphometry reference data, revealing age-related increases in bone volume and cortical width. These findings enhance the application of bone histomorphometry in pediatric research.

Area of Science:

  • Pediatric Bone Biology
  • Skeletal Development
  • Histomorphometry

Background:

  • Bone histomorphometry offers vital insights into bone development.
  • Lack of pediatric reference data has limited its clinical application.
  • This study addresses this gap by providing normative pediatric data.

Purpose of the Study:

  • To establish reference ranges for pediatric bone histomorphometry.
  • To analyze age-dependent changes in bone parameters in children and adolescents.
  • To assess the reproducibility of histomorphometric measurements in pediatric bone samples.

Main Methods:

  • Collected iliac bone samples from 58 pediatric subjects (1.5-22.9 years).
  • Performed histomorphometric analysis on cancellous and cortical bone parameters.

Related Experiment Videos

  • Utilized tetracycline labeling for dynamic bone formation assessment.

    • Main Results:

    • Significant age-dependent increases in cortical width and cancellous bone volume (due to trabecular thickness).
    • Decreased bone formation markers (activation frequency, mineral apposition rate) with age.
    • Stable osteoid thickness and bone resorption parameters across age groups.

    Conclusions:

    • Established essential reference data for pediatric bone histomorphometry.
    • Demonstrated significant age-related changes in bone structure and remodeling dynamics.
    • Highlighted the reliability of structural and dynamic parameters for pediatric bone analysis.