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Heritability heightens brain metabolite differences in schizophrenia
1Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan. fukuzako@med4.kufm.kagoshima-u.ac.jp
Abstract:
Single-voxel proton magnetic resonance spectroscopy was performed in 64 medicated schizophrenic patients and 51 healthy subjects. Spectra were obtained from a voxel in the left medial temporal lobe by using a 2.0-tesla whole-body magnetic resonance imaging system. Schizophrenic patients showed a lower N-acetylaspartate/ creatine-phosphocreatine ratio than did healthy subjects, and this reduction was greater in 13 patients with a family history of psychotic disorders.