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Interactions of galanin and morphine in the spinal antinociception in rats with mononeuropathy
Y P Zhang1, T Lundeberg, L C Yu
1Department of Physiology and National Laboratory of Biomembrane and Membrane Biotechnology, College of Life Science, Peking University, Beijing, China.
Brain Research
|March 11, 2000
Abstract:
The increased hind-paw withdrawal latency (HWL) to thermal stimulation and hind-paw withdrawal threshold (HWT) to mechanical stimulation induced by morphine were attenuated by intrathecal injection of 1 or 3 nmol, but not 0.3 nmol of the selective galanin antagonist galantide. The result indicated a possible interaction between galanin and opioids in the transmission of presumed nociceptive information in the spinal cord of rats with mononeuropathy.