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Finding function through structural genomics.

L Shapiro¹, T Harris

¹Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA. shapiro@anguilla.physbio.mssm.edu

Current Opinion in Biotechnology

|February 19, 2000

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High-throughput sequencing provides vast protein databases, but many protein functions remain unknown. Deciphering these functions is a key challenge in modern experimental biology.

Area of Science:

Genomics
Proteomics
Molecular Biology

Background:

The advent of high-throughput sequencing technologies has generated extensive genomic and proteomic data.
Large databases of protein sequences are now available, stemming from whole-genome sequencing and cDNA analysis.

Purpose of the Study:

To address the challenge of determining the functions of numerous proteins with unknown roles.
To highlight the significance of functional genomics and proteomics in experimental biology.

Main Methods:

Analysis of whole-genome sequences.
High-throughput cDNA sequencing and analysis.
Bioinformatic approaches for protein sequence analysis.

Main Results:

Related Experiment Videos

Creation of large databases containing numerous protein sequences.
Identification of a substantial number of proteins with uncharacterized functions.

Conclusions:

Deciphering the functions of newly identified proteins is a critical next step in biological research.
The current data landscape presents a significant intellectual challenge for the scientific community.