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Related Experiment Videos

High-throughput and ultra-high-throughput screening: solution- and cell-based approaches.

S A Sundberg1

  • 1Caliper Technologies Corporation, CA 94043, USA. steve. sundberg@calipertech.com

Current Opinion in Biotechnology
|February 19, 2000
PubMed
Summary
This summary is machine-generated.

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Miniaturization trends drive development of fluorescence assays in microplates. Microfluidic devices enable continuous-flow screening, reducing reagent use and enhancing assay functionality for high-throughput applications.

Area of Science:

  • Biochemistry
  • Assay Development
  • Microfluidics

Background:

  • The demand for high-throughput and ultra-high-throughput screening fuels assay miniaturization.
  • Homogeneous, fluorescence-based assays are increasingly developed for microplate formats with higher density and smaller volumes.

Purpose of the Study:

  • To explore the application of first-generation microfluidic devices for biochemical and cell-based assays.
  • To highlight the potential of microfluidics in reducing reagent consumption and enhancing screening capabilities.

Main Methods:

  • Development of first-generation microfluidic devices.
  • Implementation of continuous-flow assays for biochemical and cell-based applications.

Main Results:

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  • Microfluidic devices facilitate continuous-flow biochemical and cell-based assays.
  • Significant reduction in reagent consumption (orders of magnitude) was achieved.

Conclusions:

  • Microfluidic devices offer a promising platform for miniaturized, high-throughput screening.
  • These devices integrate compound handling with unique assay functionalities, advancing screening technology.