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Kinesins and microtubules: their structures and motor mechanisms
1Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA. sablin@msg.ucsf.edu
Current Opinion in Cell Biology
|February 19, 2000
Abstract:
Atomic resolution three-dimensional structures of two oppositely directed kinesin motors - conventional kinesin and non-claret disjunctional (ncd) protein - are now available in their functional dimeric form. A detailed model of the microtubule has also been recently obtained by docking the 3.7 A structure of tubulin into a 20 A map of the microtubule. Recent structural studies of kinesin motors and their microtubule tracks are contributing to our current understanding of kinesin motor mechanisms.