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Transcriptional mechanisms in the development of motor control
L W Jurata1, J B Thomas, S L Pfaff
1Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, 92037, USA. ljurata@ems.salk.edu
Current Opinion in Neurobiology
|February 19, 2000
Abstract:
Considerable progress has been made in understanding how combinatorially expressed transcription factors control the development of neuronal subtypes in the fly and vertebrate central nervous systems. The mode of action of many of these factors has been conserved from invertebrates to vertebrates throughout evolution, such as the formation and regulation of specific transcriptional complexes, the utilization of repressors for maintaining specificity, and the use of phosphorylation as an important means for transiently altering transcriptional activity.