Recognition of distorted DNA structures by HMG domains
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1Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK. aat@mrc-lmb.cam.ac.uk
Current Opinion in Structural Biology
|February 19, 2000
Abstract:
Recent biochemical and structural studies have shown that the preferential recognition of distorted DNA structures, including DNA bulges, four-way junctions and cis-platinated DNA, by HMG domains is dependent on residues immediately preceding the second alpha helix of the L-shaped HMG domain.
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