Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Severity prediction rules in community acquired pneumonia: a validation study.

W S Lim1, S Lewis, J T Macfarlane

  • 1Respiratory Medicine, City Hospital, Nottingham NG5 1PB, UK.

Thorax
|February 19, 2000
PubMed
Summary

The British Thoracic Society rule (BTSr) and its modified version (mBTSr) showed limited accuracy in predicting community-acquired pneumonia mortality in a UK study. Key factors like age, confusion, and urea levels were significant predictors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BTS guidelines for the management of community acquired pneumonia in adults: update 2009.

Thorax·2009
Same author

Microbiology investigations in community acquired pneumonia--most laboratories in England and Wales do not offer all those recommended in the British Thoracic Society guideline.

The Journal of infection·2008
Same author

Ethical planning for an influenza pandemic.

Clinical medicine (London, England)·2008
Same author

2004 update of BTS pneumonia guidelines: what's new?

Thorax·2004
Same author

Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study.

Thorax·2003
Same author

Percutaneous lung biopsies: a survey of UK practice based on 5444 biopsies.

The British journal of radiology·2002

Area of Science:

  • Pulmonology
  • Critical Care Medicine
  • Epidemiology

Background:

  • The British Thoracic Society developed a rule (BTSr) to predict short-term mortality in community-acquired pneumonia (CAP).
  • Neither the BTSr nor its modified version (mBTSr) have been validated in the UK population.
  • A validation study was needed to assess these rules and identify predictive factors in a UK cohort.

Purpose of the Study:

  • To determine clinical factors predictive of in-hospital mortality in CAP patients.
  • To assess the performance of the BTSr and mBTSr in a UK population.

Main Methods:

  • A case-control study was conducted using data from five hospitals in the Mid Trent area.
  • Cases included all CAP patients who died in 1997; controls were randomly selected survivors.

Related Experiment Videos

  • Medical records were reviewed to identify mortality predictors and evaluate the BTSr and mBTSr performance.

    • Main Results:

    • Independent predictors of mortality included age >65, temperature <37°C, respiratory rate >24/min, mental confusion, urea >7 mmol/l, sodium <135 mmol/l, and pleural effusion.
    • The BTSr demonstrated 52% sensitivity and 79% specificity.
    • The mBTSr showed 66% sensitivity and 73% specificity.

    Conclusions:

    • The predictive value of mental confusion, elevated respiratory rate, and raised urea in the mBTSr was confirmed.
    • Both BTSr and mBTSr performed less effectively in this UK validation cohort, particularly with a high proportion of elderly patients (48% aged ≥75 years).
    • Further validation and potential refinement of severity rules are necessary for diverse patient populations.