Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional genomics and DNA array techniques in atherosclerosis research.

M O Hiltunen1, M Niemi, S Ylä-Herttuala

  • 1A.I. Virtanen Institute, University of Kuopio, Finland.

Current Opinion in Lipidology
|February 19, 2000
PubMed
Summary

DNA arrays enable simultaneous analysis of gene expression for genomic DNA. This technology is crucial for understanding atherosclerosis mechanisms and developing new therapeutic strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GWAS of Second-Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Wildlife-vehicle collision liability in Europe: A review of existing approaches and their implications.

Journal of environmental management·2025
Same author

Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis.

Scientific reports·2025
Same author

BMP2 gene transfer induces pericardial effusion and inflammatory response in the ischemic porcine myocardium.

Frontiers in cardiovascular medicine·2023
Same author

SproutAngio: an open-source bioimage informatics tool for quantitative analysis of sprouting angiogenesis and lumen space.

Scientific reports·2023
Same author

Decreased Gray-White Matter Contrast of [11C]-PiB Uptake in Cognitively Unimpaired Subjects with Severe Obstructive Sleep Apnea.

The journal of prevention of Alzheimer's disease·2022

Area of Science:

  • Genomics
  • Molecular Biology
  • Cardiovascular Research

Background:

  • DNA arrays are transforming gene expression and single nucleotide polymorphism analysis.
  • Current DNA arrays analyze 10-15% of human genes, with future potential for whole-genome analysis.
  • Understanding gene expression in atherosclerosis is vital for identifying novel therapeutic targets.

Purpose of the Study:

  • To review DNA array technology.
  • To highlight applications of DNA arrays in atherosclerosis research.

Main Methods:

  • Review of current DNA array formats (cDNA, oligonucleotide-based).
  • Discussion of DNA array capabilities for analyzing gene expression.
  • Focus on identifying transcriptional events in atherogenesis.

Related Experiment Videos

Main Results:

  • DNA arrays allow simultaneous analysis of multiple genes.
  • They provide insights into the function, hierarchy, and interactions of genetic programs.
  • Identification of gene expression patterns related to atherosclerosis.

Conclusions:

  • DNA array technology is revolutionizing biological research, drug development, and diagnostics.
  • Application of DNA arrays in atherosclerosis research facilitates the identification of therapeutic strategies.
  • This technology offers a powerful tool for dissecting complex diseases at the molecular level.