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Apheresis.

G G Illei1, J H Klippel

  • 1Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA. illeig@exchange.nih.gov

Rheumatic Diseases Clinics of North America
|February 19, 2000
PubMed
Summary
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Ancient humoral removal therapies, now using apheresis, show limited clinical trial benefits for rheumatic diseases like lupus and rheumatoid arthritis despite case reports. Further research is needed for effective treatment.

Area of Science:

  • Medical history
  • Hematology
  • Rheumatology

Background:

  • Ancient medical practices involved removing "pathologic humors" for poorly understood diseases.
  • Modern apheresis, enabled by blood banking technology, offers a contemporary approach to humoral removal.

Purpose of the Study:

  • To evaluate the efficacy of apheresis in managing major rheumatic diseases.
  • To assess the current role of apheresis in rheumatologic disorder treatment.

Main Methods:

  • Review of clinical trial data and case reports on apheresis in rheumatic diseases.
  • Analysis of apheresis application in systemic lupus erythematosus and rheumatoid arthritis.

Main Results:

  • Numerous case reports suggest clinical benefits of apheresis in rheumatologic disorders.

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  • Clinical trial data present discouraging results regarding apheresis efficacy.
  • Apheresis appears to have a limited role in current rheumatic disease management.

    • Conclusions:

    • Despite historical context and technological advancements, apheresis shows limited proven benefit in major rheumatic diseases based on clinical trials.
    • The role of apheresis in managing systemic lupus erythematosus and rheumatoid arthritis requires further investigation and validation through robust clinical trials.