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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Case reports. Invasive pulmonary aspergillosis in non-neutropenic patients treated with liposomal amphotericin B

Y Zhirong, L Wanqing, P Weihua

    Mycoses
    |February 19, 2000
    PubMed

    Insights

    Two patients with invasive pulmonary aspergillosis, caused by Aspergillus flavus and Aspergillus fumigatus, were successfully treated with liposomal amphotericin B. This antifungal therapy led to complete recovery without severe adverse effects in both immunocompromised individuals.

    Area of Science:

    • Mycology
    • Infectious Diseases
    • Pulmonology

    Background:

    • Invasive pulmonary aspergillosis is a serious fungal infection, particularly in immunocompromised patients.
    • Chronic nephritis and malignant lymphoma are risk factors for invasive fungal infections.

    Observation:

    • Two cases of invasive pulmonary aspergillosis are presented.
    • One patient had chronic nephritis and was infected with Aspergillus flavus.
    • The other patient had malignant lymphoma and was infected with Aspergillus fumigatus.

    Findings:

    • Both patients received intravenous liposomal amphotericin B.
    • Treatment duration was 31 days for the first patient and 35 days for the second.
    • Complete cure was achieved in both cases.

    Implications:

    • Liposomal amphotericin B is an effective treatment for invasive pulmonary aspergillosis.
    • The therapy is well-tolerated, with no severe adverse effects reported.
    • Successful treatment outcomes highlight the importance of timely antifungal intervention in at-risk populations.

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