Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Clinical evaluation of amino acid solution].

M Pertkiewicz1, R Słotwiński, K Majewska

  • 1Katedry i Kliniki Chirurgii Gastroenterologicznej i Zywienia Akademii Medycznej w Warszawie.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|February 19, 2000
PubMed
Summary

Supplementing total parenteral nutrition (TPN) with glutamine improved clinical status and immune function in critically ill septic patients. This nutritional support enhanced nitrogen balance, body composition, and plasma protein levels without side effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Degradation kinetics and mechanism of pentoxifylline by ultraviolet activated peroxydisulfate.

RSC advances·2022
Same author

The role of tumor markers and biomarkers in colorectal cancer.

Neoplasma·2013
Same author

Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide--analyses from a randomised, placebo-controlled study.

Clinical nutrition (Edinburgh, Scotland)·2013
Same author

Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL™) scale.

Clinical nutrition (Edinburgh, Scotland)·2013
Same author

Differences in proteolytic activity and gene profiles of fungal strains isolated from the total parenteral nutrition patients.

Folia microbiologica·2011
Same author

Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome.

Gut·2011

Area of Science:

  • Clinical Nutrition
  • Immunology
  • Critical Care Medicine

Background:

  • Glutamine is vital for immune function and is being incorporated into total parenteral nutrition (TPN).
  • Critically ill septic patients often experience clinical and nutritional deficits despite conventional TPN.
  • The role of glutamine supplementation in TPN for this patient group requires further investigation.

Purpose of the Study:

  • To evaluate the impact of glutamine-supplemented TPN on clinical status, body composition, protein synthesis, and immune function in critically ill patients with sepsis.
  • To assess the safety and efficacy of glutamine in TPN for patients with severe infections.

Main Methods:

  • Eleven critically ill septic patients received glutamine-supplemented TPN for 10 days after a period on conventional TPN.

Related Experiment Videos

  • Clinical status, body composition, and body water distribution were monitored.
  • Venous blood samples were analyzed for cellular immunity, plasma albumin, transferrin, and triglycerides.
  • Nitrogen balance was calculated daily.

    • Main Results:

    • Patients receiving glutamine-supplemented TPN showed improved nitrogen balance, body composition, and body water distribution.
    • Significant increases in plasma protein concentrations (albumin, transferrin) and immunological indices were observed.
    • No adverse side effects were reported during the glutamine supplementation period.

    Conclusions:

    • Glutamine supplementation in TPN demonstrates beneficial effects on nitrogen balance, plasma proteins, and immune status in critically ill septic patients.
    • This nutritional strategy appears safe and effective for improving outcomes in this vulnerable population.
    • Further research is warranted to optimize glutamine dosage and duration in TPN for sepsis management.