[A quantitative study of microvascular density and proliferating cell ratio in buccal mucosa squamous cell carcinoma]

By the ABC enzyme labelling method we studied the microvascular density and proliferating cell ratio in buccal mucosa squamous cell carcinoma (BMSCC) and in normal buccal tissues quantitatively. These two parameters in BMSCC are 208% and 335% (P < 0.05) respectively which are distinctly higher than those of the normal buccal tissues, indicating malignant features of the carcinoma. The distribution of proliferating cells, corresponds to the area where the microvascular density is high, mainly in the periphery and basal parts of cancer nests. There is a dependent relationship between them, showing a linear positive correlation statistically. The results confirm that angiogenesis and cancer cell proliferation promote each other. They are two important indexes of the local biological behavior of BMSCC and are very important to predict the malignant potential and to evaluate therapeutic effect for BMSCC.