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Genetic analysis of vitamin D related genes in Canadian multiple sclerosis patients. Canadian Collaborative Study
J L Steckley1, D A Dyment, A D Sadovnick
1Wellcome Trust Centre for Human Genetics, University of Oxford, England.
Abstract:
The objective of this study was to investigate genes involved in the metabolism and function of vitamin D as candidate genes for genetic susceptibility to MS. Restriction fragment length polymorphisms and highly polymorphic microsatellite markers within or very close to the 1,25(OH)2D3 receptor (VDR) [12q14], the vitamin D binding protein (DBP) [4q12], and the 25(OH)D2 1alpha-hydroxylase [12q13] loci were analyzed for linkage or association with MS. We found no evidence for linkage or association of these candidate genes with MS in the Canadian population.
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