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Anti-inflammatory drugs and Alzheimer-type pathology in aging
1Department of Pathology and Laboratory Medicine, Vancouver General Hospital and the University of British Columbia, Canada. imackenz@vanhosp.bc.ca
Neurology
|February 19, 2000
Abstract:
Anti-inflammatory drugs have been suggested as a treatment for AD. The authors examined the AD-type pathology in postmortem brain tissue from elderly nondemented individuals who were chronically exposed to anti-inflammatory drugs. The results suggest that 1) these drugs do not affect the formation of either senile plaques or neurofibrillary tangles and 2) nonsteroidal anti-inflammatory drugs may be more effective than steroids in treating AD because of their ability to suppress the microglial activation associated with senile plaques.