Related Experiment Video
Updated: Jul 25, 2026

The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects
Published on: October 2, 2014
Late shunt infections
C Baird1, D O'Connor, T Pittman
1Division of Pediatrics, Cardinal Glennon Children's Hospital, St. Louis, MO 63104-1095, USA.
Abstract:
We reviewed the records of the 957 shunt-related operations performed at Cardinal Glennon Children's Hospital over a 10-year period. During that time, 94 shunt infections were recognized. Eight of the infections occurred more than 9 months postoperatively. These differed from early infections in two ways: (1) Staphylococcus aureus was not found to be a pathogen in any late infection. (2) Abdominal pseudocysts were much more frequently found in patients with late-developing infections. In addition, the pathogens involved and the temporal distribution of cases suggest most infections that occur more than 9 months postoperatively are more likely caused by secondary bacterial seeding than by bacterial inoculation at the time of operation.
Insights
Late shunt infections in children are often caused by secondary bacterial seeding, not initial surgical contamination. These late infections, occurring over 9 months postoperatively, commonly feature abdominal pseudocysts and lack Staphylococcus aureus.
Area of Science:
- Pediatric Neurosurgery
- Infectious Diseases
- Medical Device Complications
Background:
- Shunt-related operations are common in pediatric neurosurgery for conditions like hydrocephalus.
- Shunt infections are a significant complication, potentially leading to reoperation and increased morbidity.
- Understanding the timing and characteristics of shunt infections is crucial for effective management.
Purpose of the Study:
- To analyze the incidence and characteristics of late-onset shunt infections (occurring >9 months postoperatively).
- To compare late-onset infections with early-onset infections.
- To investigate the potential causes of late-onset shunt infections.
Main Methods:
- Retrospective review of 957 shunt-related operations performed over a 10-year period.
- Identification and analysis of 94 recognized shunt infections.
- Categorization of infections into early (<9 months) and late (>9 months) postoperative periods.
Main Results:
- A total of 94 shunt infections were identified.
- Eight infections occurred more than 9 months postoperatively.
- Late infections were characterized by the absence of Staphylococcus aureus and a higher frequency of abdominal pseudocysts compared to early infections.
Conclusions:
- Late-onset shunt infections (>9 months) exhibit distinct characteristics from early-onset infections.
- The findings suggest that late-onset shunt infections are more likely due to secondary bacterial seeding rather than initial inoculation during surgery.
- Abdominal pseudocysts may be a significant clinical indicator of late-developing shunt infections.
Related Concept Videos
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Endocarditis I: Introduction
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis III: Medical Management
Endocarditis IV: Nursing Management
Brain Abscess l: Introduction

