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Low-dose radiosurgery for meningiomas
K Nakaya1, M Hayashi, S Nakamura
1Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Tokyo, Japan. kanakaya@nij.twmu.ac.jp
Stereotactic and Functional Neurosurgery
|February 22, 2000
Summary
Lower-dose Gamma Knife radiosurgery (GKRS) is a viable treatment option for meningiomas, even for large or critical structure-adjacent tumors. This approach demonstrated no tumor growth in 11 cases, suggesting its potential efficacy.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Meningiomas are primary tumors of the brain and spinal cord.
- Gamma Knife radiosurgery (GKRS) is a standard treatment for meningiomas.
- Delivering optimal GKRS doses can be challenging for large tumors or those near critical structures.
Purpose of the Study:
- To evaluate the efficacy of lower-dose Gamma Knife radiosurgery for treating meningiomas.
- To assess tumor response and adverse events in patients receiving GKRS with margin doses not exceeding 10 Gy.
Main Methods:
- Retrospective analysis of 11 meningioma cases treated with GKRS.
- Margin dose was intentionally kept below 10 Gy.
- Follow-up included imaging and clinical assessment for over 12 months.
Main Results:
- No tumor growth was observed in any of the 11 cases after GKRS.
- Four tumors showed shrinkage, and seven remained unchanged.
- Transient oculomotor palsy occurred in two patients; no other adverse events were reported.
Conclusions:
- Lower-dose Gamma Knife radiosurgery (GKRS) is a safe and effective treatment option for meningiomas.
- This approach can be considered for large tumors or those adjacent to critical structures, where optimal dosing is challenging.