[Changes of plasma testosterone level in male patients with coronary heart disease]

The plasma testosterone (T), estrodiol (E), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), HDL2-C, HDL3-C, apolipoprotein (apo) A1 and B100, and lipoprotein (a) [Lp(a)] were measured in 118 male patients with coronary heart disease (CHD) and 53 sex and age-matched healthy controls. The results showed that plasma T, HDL-C, HDL3-C levels and HDL-C/TC ratio were significantly lower and Lp(a) level was significantly higher in patients than in the controls. After adjusting body mass index, blood pressure and fasting blood glucose, the difference of plasma level between patients and controls persisted. Plasma T level correlated positively with the HDL-C, HDL3-C level and HDL-C/TC ratio and negatively with systolic blood pressure, apoB100 and Lp(a) level. Logistic regression was used to analyze the data, and this indicated that decreased T and HDL3-C levels, and increased Lp(a) level were the independent risk factors of CHD.