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Concordance between use of proton pump inhibitors and prescribing guidelines
P I Pillans1, P A Kubler, J M Radford
1Department of Clinical Pharmacology, Princess Alexandra Hospital, Brisbane, QLD. pillansp@health.qld.gov.au
Objective:
To determine (i) the relationship between prescriptions for proton pump inhibitors (PPIs) and upper gastrointestinal conditions, and (ii) compliance with Pharmaceutical Benefits Scheme (PBS) prescribing guidelines for PPIs.
Design:
Drug utilisation evaluation.
Setting:
800-bed metropolitan teaching hospital.
Participants:
253 patients dispensed PPIs from the hospital pharmacy over five consecutive weeks (11 January to 15 February 1999).
Main Outcome Measures:
Recorded gastrointestinal conditions; previous trial of H2-antagonist therapy; compliance with PBS criteria for prescribing PPIs.
Results:
Seventy patients (27.7%) had no appropriate upper gastrointestinal tract investigations, and 62 patients (24%) did not receive an adequate trial of H2-antagonist therapy before the commencement of a PPI. The major indications for use of PPIs in investigated patients were gastro-oesophageal reflux in 99 (54%) and peptic ulcer disease in 30 (16.4%). In only 57 patients (22.5%) did PPI prescriptions comply with PBS prescribing guidelines. Clinical indications that failed to meet prescribing criteria included milder forms of gastro-oesophageal reflux, gastritis/duodenitis, and non-specific dyspepsia with normal endoscopy results.
Conclusion:
Drug utilisation data indicate widespread use of PPIs outside current prescribing guidelines. Many patients have not had relevant investigations and/or an adequate trial of H2-antagonist therapy. These findings explain the considerable hospital expenditure on PPIs.