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Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
Published on: June 18, 2013
[Changes of carbohydrate metabolism in normal pregnancy and its relationship with placental lactogen concentrations]
1First Affiliate Hospital of Sun Yat-sen Univeristy of Medical Sciences, Guangzhou 510080.
Objective:
To observe the changes of glucose metabolism and its relationship with human placental lactogen (HPL) in normal pregnant women.
Method:
94 normal pregnant women had their serum HPL concentration tested and had undergone a 75 g oral glucose tolerance tests (OGTT). Both serum insulin and glucose levels at different time intervals were determined, and the areas under curve (IAUC, GAUC) were caculated, also insulin resistance (IAI) was evaluated.
Results:
GAUC, IAUC, IAI and HPL are all significantly increased with advance of gestation (P < 0.05). Multiple correlation coefficient study demonstrated that HPL is significantly positively correlated with GAUC, IAUC and IAI(P < 0.001). But when IAUC and IAI were controlled, the relationship between HPL and GAUC was not found.
Conclusion:
There are hyperinsulinemia and insulin resistance during pregnancy, and they are related to HPL. HPL is one of the factors that contributing to carbohydrate metabolism changes during pregnancy.
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