[Study on the activity of platelets protein kinase C in patients with pregnancy induced hypertension]

To investigate the relationship between the activity of protein kinase C (PKC) in plateletes and patients with pregnancy induced hypertension (PIH).

Activities of PKC in membrance of platelets, which came from 18 PIH patients(PIH group), 20 normal pregnant women (normal pregnant group) and 20 healthy women (control group), were measured by substrate protein phosphoylation method.

Activities of PKC in the membrane and cytosolic of platelets from normal pregnancie are lower than those from control group significantly (P < 0.01). Activities of PKC in the membrane and cytosolic of platelets from PIH group are higher than those from normal pregnancie (P < 0.05). Activity of PKC in membrane of platelets from mild and moderate PIH group is higher than that from normal pregnancie (P < 0.01). However, there is no difference between the activities of PKC in cytosolic of platelets from the two groups (P > 0.05). Activities of PKC in membrane and cytosolic of platelets from severe PIH were higher than those from normal pregnancie significantly (P < 0.01, P < 0.05). We also found that the activity of PKC in cytosolic of platelets from severe PIH group was significantly higher than that from mild and PIH cases, though there was no significantly difference in the activity of PKC in membrane of platelets between the two groups.

Activity of PKC in platelets relates to the occurrence and development of PIH syndrome.