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Published on: November 5, 2010
[A study of genetic epidemiology on child bronchial asthma]
Objective:
To examine the relationship between child bronchial asthma and genetic fastor.
Methods:
A case-control study including 372 pedigree was carried out.
Results:
Child bronchial asthma had obvious familiar clustering (chi 2 = 24.8, P < 0.01). The prevalence rate of the first and the second degree relatives of proband was significally higher than that of the controls. The segregation ration of asthma was 0.14 (95% CL 0.098-0.18). The h2 of the first and second degree relatives of asthma were 78.18% and 55.02%, of which 83.64% for female and 73.48% for male.
Conclusion:
The genetic model of asthma belonged to polygenetics. Genetic fastor was a main risk fastor for asthma, especially for female patients.
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