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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Introduction to Epidemiology01:26

Introduction to Epidemiology

Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Updated: Jun 18, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

[Genetic epidemiological study of asthma in general].

Y Jin1, C Chen, Y Xu

  • 1Department of Environmental Health, Anhui Medical University, Hefei, China.

Wei Sheng Yan Jiu = Journal of Hygiene Research
|February 22, 2000
PubMed
Summary
This summary is machine-generated.

Parental asthma history significantly increases offspring asthma risk by 4-8 times. Genetic factors play a crucial role in asthma development, independent of parental airway responsiveness.

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Area of Science:

  • Genetic Epidemiology
  • Respiratory Medicine
  • Pediatric Asthma

Background:

  • Asthma is a complex respiratory condition with a known familial component.
  • Understanding the genetic underpinnings of asthma is crucial for effective prevention and treatment strategies.

Purpose of the Study:

  • To investigate the role of genetic factors in asthma inheritance within nuclear families.
  • To quantify the risk of asthma in offspring based on parental asthma history.

Main Methods:

  • Analysis of genetic epidemiology data from 641 nuclear families.
  • Statistical evaluation of risk factors associated with parental asthma history.

Main Results:

  • Offspring with a parental history of asthma faced a 4.0-8.0 times higher risk (P < 0.01).
  • The risk was consistent for both sons and daughters.
  • Parental airway responsiveness did not correlate with offspring airway responsiveness.

Conclusions:

  • Genetic factors significantly contribute to the risk of developing asthma.
  • Family history is a strong predictor of asthma susceptibility in offspring.