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Sustained ventricular tachycardia and its successful prophylaxis during high-dose bolus interleukin-2 therapy for
L Oleksowicz1, P Escott, G C Leichman
1Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Abstract:
In the setting of interleukin-2 (IL-2) administration, tachycardias of ventricular origin are classified as serious, grade IV toxicities, necessitating the discontinuation of therapy. In this report, we describe a patient with renal cell carcinoma who experienced ventricular tachycardia while undergoing treatment with high-dose bolus IL-2. Prophylaxis with sotalol permitted the successful completion of his first cycle of treatment, without any recurrent rhythm disturbances.
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