Left ventricular diastolic dysfunction in patients with hypertension and preserved systolic function

Related Experiment Video

Updated: Oct 17, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
08:57

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Published on: May 22, 2026

K Yamamoto1, D J Wilson, V J Canzanello

  • 1Division of Cardiovascular Diseases, Mayo Clinic Rochester, MN 55905, USA.

Mayo Clinic Proceedings
|February 23, 2000
PubMed

Insights

Comprehensive Doppler analysis is crucial for detecting diastolic dysfunction in hypertensive patients, as transmitral flow alone often underestimates its prevalence. This method improves diagnostic accuracy for early detection and management.

Area of Science:

  • Cardiology
  • Echocardiography
  • Hypertension Research

Background:

  • Hypertension is a significant risk factor for cardiovascular disease.
  • Diastolic dysfunction can precede systolic dysfunction in hypertensive individuals.
  • Early detection of diastolic dysfunction is vital for timely intervention.

Purpose of the Study:

  • To evaluate diastolic function in hypertensive patients with preserved left ventricular systolic function.
  • To highlight the limitations of transmitral flow velocity curves in diagnosing diastolic dysfunction.
  • To compare the diagnostic yield of transmitral Doppler versus comprehensive Doppler analysis.

Main Methods:

  • Prospective study involving 51 hypertensive patients.
  • Preserved left ventricular systolic function was confirmed in all participants.
  • Comprehensive Doppler echocardiography, including transmitral and pulmonary venous flow, was performed.

Main Results:

  • Transmitral Doppler alone identified diastolic dysfunction in 31% of patients.
  • Comprehensive Doppler analysis revealed a higher prevalence of 55% (P < .05).
  • A significant number of patients initially showing a 'normal' transmitral signal were reclassified with diastolic dysfunction ('pseudonormal' pattern).

Conclusions:

  • Transmitral Doppler analysis alone frequently underestimates diastolic dysfunction in hypertensive patients.
  • Comprehensive Doppler assessment is essential for accurate diagnosis.
  • Patients at risk for diastolic dysfunction require thorough echocardiographic evaluation.
Abstract

More Related Videos

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...