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Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Hypothetical double-helical poly(A) formation in a cell and its possible biological significance
1Molecular Biophysics Department, Ukrainian National Academy of Sciences, Kyiv, Ukraine. svitlana@imbig.kiev.ua
IUBMB Life
|February 23, 2000
Abstract:
Arguments are presented in favor of capability of poly(A)-tracts of cellular RNA to form double helices in vivo. It is suggested that formation of the double helix in the mRNA poly(A) tall provides the basis for such processes as polyadenylation termination, PAB I synthesis autoregulation, and stabilization of ARE-containing mRNA by ELAV-like proteins.
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