Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Bone histomorphometric changes in ovariectomized goat at different time courses].

L Li1, W Wu, H Chen

  • 1Biomedical Engineering Research Unit, School of Basic Medicine Sciences, Chengdu.

Hua Xi Yi Ke Da Xue Xue Bao = Journal of West China University of Medical Sciences = Huaxi Yike Daxue Xuebao
|February 23, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adrenocorticotropic hormone-secreting pheochromocytomas: the exception to the rule.

Surgery·1995
Same author

The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha.

The Journal of biological chemistry·1995
Same author

Circadian variation in coronary tone in patients with stable angina. Protective role of the endothelium.

Circulation·1995
Same author

Purification of a heteromeric CCAAT binding protein from Neurospora crassa.

Molecular & general genetics : MGG·1995
Same author

Requirement for neuregulin receptor erbB2 in neural and cardiac development.

Nature·1995
Same author

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

Proceedings of the National Academy of Sciences of the United States of America·1995
Same journal

[Determination of warfarin in plasma by HPLC and an investigation of monitoring patients after cardiac valve replacement].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao·2003
Same journal

[Improved APAAP immunocytochemical staining-trace cytotoxicity test plate method for detection of cell surface antigens].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao·2003
Same journal

[Clinical application and evaluation of polymerase chain reaction-microwell plate hybridization assay in the detection of Mycobacterium tuberculosis].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao·2003
Same journal

[Study on the chemosensitivity test of human gastric cancer using the MTT assay].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao·2003
Same journal

[Investigation on the value of applying interventional radiologic treatment in the management of advanced gynecological malignancies].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao·2003
Same journal

[Study on bolus cyclosphamide treatment for 64 cases of lupus nephritis].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao·2003
See all related articles

Ovariectomy in goats causes significant bone loss and structural changes, mimicking osteopenia. This study establishes the ovariectomized goat as a valuable model for osteoporosis research.

Area of Science:

  • Veterinary Pathology
  • Bone Biology
  • Animal Models

Context:

  • Ovariectomy-induced bone loss is a significant concern in animal research.
  • Understanding the temporal progression of bone changes is crucial for developing effective treatments.
  • Goats offer a large animal model for studying skeletal diseases.

Purpose:

  • To investigate the histomorphometric bone changes in ovariectomized (OVX) goats over time.
  • To characterize the progression of osteopenia in this animal model.
  • To validate the OVX goat as a model for postmenopausal osteoporosis.

Summary:

  • Histomorphometric analysis of iliac crest biopsies in OVX goats revealed progressive bone loss.
  • Control goats maintained stable bone structure, while OVX goats showed decreased trabecular quantity and connectivity.

Related Experiment Videos

  • Significant thinning of trabeculae, increased marrow cavity, and osteopenia-like changes were observed in OVX goats by 120-180 days post-surgery.

    • Impact:

    • Provides detailed temporal bone histomorphometric data in OVX goats.
    • Supports the use of the OVX goat as a relevant preclinical model for osteoporosis.
    • Informs future research on osteoporosis mechanisms and therapeutic interventions in a large animal model.