[Changes of cerebral blood flow during hypoxicischemic encephalopathy in newborn pigs]

This study was designed to explore the change of cerebral blood flow during hypoxic-ischemic encephalopathy (HIE). Sixteen newborn pigs were devided into four groups: the normal control, 15 minutes after HIE, 30 minutes after HIE and 60 minutes after HIE. The shapes of the cerebral blood vessels were obsessed by the prepared Chinese ink irrigation and the width and volume fraction of capillary were tested and analyzed by stereographic method respectively. The results showed the small blood vessels were interrupted with the passage of time. At the time of 60 minutes after HIE, capilaries almost disappeared from view, only a few ends of blood vessels in the sheap of a broken tree were seen. The width of capillaries and small veins became more and more narrow as time went on. The percentages of capillary volume fraction and small vein volume fraction became smaller and smaller (P < 0.05). These demonstrate that the fall of cerebral blood flow plays an important role in the development of HIE.