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[Resistant antibiotic analysis of methicillin-resistant staphylococcus]
Abstract:
Methicillin-resistant staphylococcus aureus is one of the important patholonic bacteria which cause nosocomial infection. In order to investigate the resistant antibiotic circumstances of this organism and hence provide foundations of prevention and treatment, we determined the resistant rates of 88 staphylococcus strains for methicillin and for other 14 kinds of commonly used antibiotics, and we determined the engendering beta-lactamase. The results showed that the isolation rate of methicillin-resistant staphylococcus aureus (MRSA) was 56%; the rate of methicillin-resistant staphylococcus coagulase-negative (MRSCoN) was 47.6%; the resistance rate and the multi-resistant rate of methicillin-resistant staphylococcus (MRS) for the 14 kinds of antibiotics were higher as compared with those of methicillin-sensitive (MSSA). Among all the tested strains, MRSA was the highest to engender beta-lactamase (92.9%); Methicillin-sensitive staphylococcus coagulase-negative (MSSCoN) was the lowest (39.4%). MRS was sensitive to vancomycin and furantoin. These suggest that when treating this bacterium, we should select these two antibiotics first.
Insights
Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of hospital infections. This study found MRSA strains exhibit high resistance to common antibiotics, suggesting vancomycin and nitrofurantoin as preferred treatments.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Nosocomial infections are frequently caused by pathogenic bacteria like Staphylococcus aureus.
- Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat in healthcare settings.
- Understanding antibiotic resistance patterns is crucial for effective infection control and treatment strategies.
Purpose of the Study:
- To determine the antibiotic resistance rates of Staphylococcus strains, focusing on methicillin resistance.
- To investigate the prevalence of beta-lactamase production in Staphylococcus strains.
- To provide data supporting the selection of appropriate antibiotics for treating Staphylococcus-related infections.
Main Methods:
- Testing 88 Staphylococcus strains for resistance to methicillin and 14 other common antibiotics.
- Assessing beta-lactamase enzyme production in the tested strains.
- Analyzing resistance rates and multi-drug resistance profiles.
Main Results:
- The isolation rate of MRSA was 56%, and methicillin-resistant coagulase-negative Staphylococcus (MRSCoN) was 47.6%.
- Methicillin-resistant Staphylococcus (MRS) strains showed higher resistance and multi-resistance rates compared to methicillin-sensitive strains.
- MRSA exhibited the highest beta-lactamase production (92.9%), while methicillin-sensitive coagulase-negative Staphylococcus (MSSCoN) had the lowest (39.4%).
Conclusions:
- Methicillin-resistant Staphylococcus strains demonstrate significant multi-drug resistance.
- Vancomycin and nitrofurantoin are identified as sensitive options for treating methicillin-resistant Staphylococcus.
- These findings support prioritizing vancomycin and nitrofurantoin in clinical treatment protocols for these infections.