The histologic evaluation of teeth transplanted between weakly disparate, genetically defimed mice

Teeth transplanted between inbred lines of mice that differ by strong histocompatibility barriers are promptly rejected. However, when only one weak antigen difference exists between donor and recipient, teeth are known tp survive indefinitely. The purpose of this study was to determine if the histocompatibility barrier could be increased to two weak antigens without inducing a rejection episode. Allografted teeth was examined from 30 to 210 days after transplantation and, contrary to expectations, the teeth were rejected at about 60 days. Thus, all but the weakest of histocompatibility barriers are sufficient to cause the rejection of tooth allotransplants in mice.