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Updated: Sep 27, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
[When disease insight is halting. II. The neurobiological underpinnings]
J E Starmark1, P H Hellström, H Agren
1Dept of Neurology, Sahlgrenska University Hospital, Göteborg. Jan-Erik.Starmark@neuro.gu.se
Abstract:
This review examines the neurobiological underpinnings of impaired insight and awareness in psychosis. Crucial mainly dopaminergic pathways are discussed in relation to delusions and hallucinations. Thirty percent of psychotic patients with impaired insight will not respond to traditional neuroleptic drug treatment, and the possibility that multifocal brain etiology might underlie such cases is discussed. It is suggested that severe cases of thought process disorder in psychosis may result from such multifocal processes.
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