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Productive replication of human adenoviruses in mouse epidermal cells
I Ganly1, V Mautner, A Balmain
1CRC Department of Medical Oncology, CRC Beatson Laboratories, Glasgow G61 1BD, Scotland.
Journal of Virology
|February 23, 2000
Abstract:
In contrast to most cells of mouse origin, cell lines derived from mouse epidermis are permissive for replication of human adenovirus type 5. The extent of epidermal cell differentiation correlated with the level of E1A expression and virus replication. Mouse epidermal cells may provide useful models for cancer therapy using replication-competent human adenoviruses.