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Nisoldipine Cardioplegia in the Isolated Rabbit Heart.

Açikel1, Hazan, Sariosmanoglu

  • 1Department of Thoracic and Cardiovascular Surgery, Dokuz Eylül University, Inciralti, Izmir, Turkey

Journal of Cardiovascular Pharmacology and Therapeutics
|February 23, 2000
PubMed
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Nisoldipine added to cardioplegia improved heart function and reduced oxidative stress after ischemia in rabbit hearts. Further clinical studies on oral nisoldipine before cardiac surgery are suggested.

Area of Science:

  • Cardiology
  • Cardiovascular Surgery
  • Pharmacology

Background:

  • Investigated metabolic and hemodynamic effects of nisoldipine in cardioplegia.
  • Studied isolated rabbit hearts subjected to ischemic injury.
  • Compared St. Thomas II cardioplegia with and without nisoldipine.

Purpose of the Study:

  • To evaluate the protective effects of nisoldipine as a cardioplegic additive.
  • To assess the impact of nisoldipine on cardiac function and oxidative stress markers post-ischemia.
  • To determine the potential of nisoldipine in preserving myocardial integrity.

Main Methods:

  • Used 13 isolated rabbit hearts perfused with Krebs-Henseleit solution.
  • Administered St. Thomas II cardioplegic solution to control group (n=6).

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  • Supplemented cardioplegic solution with nisoldipine (0.1 mg/kg) in the experimental group (n=7).
  • Measured left ventricular pressure, heart rate, and biochemical markers (malondialdehyde, glutathione enzymes, CK-MB, AST, LDH) before and after 60 minutes of ischemia.

    • Main Results:

    • Nisoldipine group showed significantly higher peak generated pressure and lower end-diastolic pressure post-ischemia.
    • Reduced malondialdehyde levels observed in the nisoldipine group, indicating less lipid peroxidation.
    • Significantly higher levels of glutathione peroxidase and glutathione reductase in the nisoldipine group suggest enhanced antioxidant defense.
    • Aspartate transaminase levels showed a significant difference between preischemic and postischemic states in the nisoldipine group.

    Conclusions:

    • Nisoldipine cardioplegia demonstrated beneficial effects on hemodynamic function and oxidative stress markers.
    • While effective in this model, direct use as a cardioplegic additive requires further investigation.
    • Oral administration of nisoldipine prior to cardiac surgery warrants clinical study.