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Serum MAGE-4 protein in ovarian cancer patients
H Kawagoe1, A Yamada, H Matsumoto
1Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, 830, Japan.
Objective:
We measured serum levels of MAGE-4 protein in patients with ovarian cancer to investigate the relationship between serum MAGE-4 positivity and prognosis.
Methods:
Serum levels of MAGE-4 protein were measured with an ELISA system.
Results:
Serum levels of MAGE-4 in patients with ovarian cancer were significantly higher than levels in patients with benign diseases. Serum MAGE-4 protein was considered positive in 22% of primary ovarian cancer patients. The positive rate was the highest in sera of patients with surface epithelial-stromal tumors, particularly serous adenocarcinomas (24%). The survival time after a primary surgical operation in ovarian cancer patients with serum MAGE-4 positivity was significantly shorter than that of MAGE-4-negative cases.
Conclusion:
These results suggest that serum MAGE-4 protein is a potential prognostic factor of reduced survival in ovarian cancer patients.