Related Experiment Videos
Comparative effects of quinacrine and erythromycin in adult female rats: a nonsurgical sterilization study
1Laboratory of Reproductive and Endocrine Toxicology, Research Triangle Institute, Research Triangle Park, North Carolina 27709, USA. patf@rti.org
Objective:
To compare the efficacies of erythromycin and quinacrine for nonsurgical sterilization in rats. Quinacrine used for nonsurgical sterilization in women is mutagenic, and most clinical regimens have had a higher failure rate than surgical sterilization.
Design:
This acute mammal study included five groups of rats assigned randomly and evaluated at two times after treatment.
Animal(S):
Adult female Sprague-Dawley rats.
Intervention(S):
Five groups of female Sprague-Dawley rats (20 per group) were given 70 or 280 mg/kg of erythromycin lactobionate, 350 mg/kg of quinacrine hydrochloride, or vehicle control administered transcervically. Rats were mated 21 days later. Additional groups (n = 4 per group) were treated and killed 21 days later without mating.
Main Outcome Measure(S):
Fourteen days after mating, numbers of ovarian corpora lutea, total uterine implants, and embryos were evaluated. For unmated animals, uterine sections were examined for fibrosis and lumen closure.
Result(S):
Neither drug altered numbers of corpora lutea. Erythromycin decreased pregnancy rate and number of implantations (increased preimplantation loss) in a dose-related fashion. Quinacrine increased resorptions. Uterine pathology was more extensive and frequent in erythromycin-treated animals, with extent and severity increasing from 21 to 35+ days.
Conclusion(S):
Erythromycin was more effective than quinacrine in preventing pregnancy.