[Topical treatment of maxillary sinusitis. Preliminary report]

Area of Science:

• Otolaryngology
• Pharmacology
• Biomaterials

Context:

• Sinusitis, a common inflammatory sinus condition, often requires multifaceted treatment approaches.
• Current treatments for sinusitis may involve systemic medications, surgical interventions, or topical therapies.
• The development of novel local treatment preparations aims to improve efficacy and patient outcomes.

Purpose:

• To introduce and evaluate a new sterile instillation preparation for the local treatment of sinusitis.
• To assess the efficacy of a gelatin-based formulation containing chloramphenicol, sulfanilamide, and prednisolone.
• To document the treatment outcomes, including healing rates and spontaneous perforation closure.

Summary:

• A novel sterile preparation for local sinusitis treatment was developed, utilizing an absorbable gelatin carrier with chloramphenicol, sulfanilamide, and prednisolone.
• An average of 2.4 instillations resulted in healing for 78.5% of patients, with some cases showing spontaneous closure of large perforations.
• While promising, the study emphasizes that surgical intervention remains crucial, and further investigation with larger patient cohorts is recommended.

Impact:

• Provides a potentially effective new topical therapeutic option for managing sinusitis.
• Demonstrates the successful application of a novel drug delivery system for localized treatment.
• Highlights the need for continued research to validate findings and optimize sinusitis management strategies.