Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiovascular dysfunction in multiple sclerosis.

A R Acevedo1, C Nava, N Arriada

  • 1Instituto Nacional de Neurología y Neurocirugía MVS Mexico City, Mexico.

Acta Neurologica Scandinavica
|February 24, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BRD4 sustains p63 transcriptional program in keratinocytes.

Biology direct·2024
Same author

Experimental Lung Transplantation Related With HIF-1, VEGF, ROS. Assessment of HIF-1alpha, VEGF, and Reactive Oxygen Species After Competitive Blockade of Chetomin for Lung Transplantation in Rats.

Physiological research·2024
Same author

Maxillofacial Injuries in Padel Game.

Journal of maxillofacial and oral surgery·2023
Same author

Mutations in the John Cunningham virus VP1 gene could predispose to the development of progressive multifocal leukoencephalopathy in multiple sclerosis patients undergoing treatment with natalizumab.

Multiple sclerosis and related disorders·2021
Same author

Hospital workers mental health during the COVID-19 pandemic: methods of data collection and characteristics of study sample in a university hospital in Milan (Italy).

BMC medical research methodology·2021
Same author

De novo truncating variants in the intronless IRF2BPL are responsible for developmental epileptic encephalopathy.

Genetics in medicine : official journal of the American College of Medical Genetics·2018
Same journal

Editorial.

Acta neurologica Scandinavica·2022
Same journal

Advances in sudden unexpected death in epilepsy.

Acta neurologica Scandinavica·2022
Same journal

Non-convulsive seizures and non-convulsive status epilepticus in neuro-intensive care unit.

Acta neurologica Scandinavica·2022
Same journal

Positron emission tomography in autoimmune encephalitis: Clinical implications and future directions.

Acta neurologica Scandinavica·2022
Same journal

Seizure detection based on wearable devices: A review of device, mechanism, and algorithm.

Acta neurologica Scandinavica·2022
Same journal

Walking confidence and perceived locomotion ability explain participation after stroke: A cross-sectional experimental study.

Acta neurologica Scandinavica·2022
See all related articles

Cardiovascular dysfunction (CD) in multiple sclerosis (MS) is common, affecting reflex pathways. Simple tests can detect subclinical CD, a significant cause of disability in MS patients.

Area of Science:

  • Neurology
  • Cardiology
  • Autonomic Neuroscience

Background:

  • Cardiovascular dysfunction (CD) in multiple sclerosis (MS) is linked to brainstem reflex pathway involvement.
  • Autonomic nervous system dysfunction is increasingly recognized as a contributor to disability in MS.
  • Understanding the prevalence and detection of CD in MS is crucial for patient management.

Purpose of the Study:

  • To investigate the presence and severity of cardiovascular dysfunction in patients with multiple sclerosis.
  • To correlate cardiovascular dysfunction with disability status (EDSS) and functional independence (FIM) in MS patients.
  • To explore the relationship between cardiovascular dysfunction and brainstem lesions on MRI in MS.

Main Methods:

  • A battery of cardiovascular tests was administered to 40 MS patients and 40 healthy controls.

Related Experiment Videos

  • Tests included postural blood pressure and heart rate changes, respiratory sinus arrhythmia, and Valsalva maneuver.
  • Patients were assessed using the Expanded Disability Status Scale (EDSS) and Functional Independence Measure (FIM); MRI scans were reviewed.

    • Main Results:

    • MS patients showed statistically significant differences in all cardiovascular tests compared to controls (P < 0.05).
    • Postural blood pressure changes and Valsalva maneuver (Tests 1 and 4) demonstrated the highest significance.
    • More severe CD correlated with higher EDSS scores and lower FIM scores, and with brainstem lesions on MRI (P < 0.01).

    Conclusions:

    • A significant proportion of MS patients exhibit cardiovascular dysfunction, often subclinical.
    • Simple bedside tests, like postural blood pressure changes, can help detect subclinical CD in MS.
    • Subclinical cardiovascular dysfunction is a relevant factor contributing to overall disability in multiple sclerosis.