Related Experiment Video
Updated: Aug 4, 2026

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine
Published on: July 24, 2018
A physiological model to predict xenobiotic concentration in fish
1Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, Canada
Abstract:
A physiological model was developed to estimate fish body toxicant load based on information regarding the chemical exposure regime, fish body weight, lipid content and oxygen uptake. The general model was tested in which an oxygen database (OXYREF) was used to predict fish toxicant body burden. Based on the quantitative analysis, it was shown that the model was reliable and accurate in estimating fish body burden of a number of non-metabolized aquatic toxicants. This modified model possesses some functional reality which enables more realistic predictions, making it useful in the practice of aquatic environmental risk assessment.
Related Concept Videos
Pharmacokinetic Models: Overview
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
Model Approaches for Pharmacokinetic Data: Physiological Models
Physiological Pharmacokinetic Models: Assumption with Protein Binding
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance
A recent model describes pravastatin's hepatobiliary excretion,...
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.

