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Complement component C6 polymorphism: novel protein-typing technique and distribution of allotypes in Germany
B Schwarzenholz1, A Correns, H Schröder
1Institute for Forensic Medicine, University Hospital Charité, Medical Faculty, Humboldt University, Berlin, Germany.
Experimental and Clinical Immunogenetics
|February 25, 2000
Abstract:
The genetic polymorphism of human C6 was investigated in Germany using an improved technique: polyacrylamide gel isoelectric focusing and subsequent direct immunofixation with monospecific C6 antisera. Typing of C6 was performed on native serum samples from 1,775 unrelated persons. The gene frequencies in the population study were as follows: C6*A 0.6313, C6*B 0.3566 and the rare alleles C6*R 0. 0121. In total, 8 rare allotypes were analysed. The gene frequencies obtained are in good agreement with those previously published.