Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Integration of genetic maps by polynomial transformations.

H H Stassen¹, C Scharfetter

¹Psychiatric University Hospital Zurich, Research Department, CH-8029 Zurich, Switzerland. k454910@bli.unizh.ch

American Journal of Medical Genetics

|February 25, 2000

Summary

Integrating genetic maps is challenging due to length variations. Polynomial transformations offer a precise method to merge genetic maps and reconstruct sex-specific recombination data.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Polypharmacy in psychiatry and weight gain: longitudinal study of 832 patients hospitalized for depression or schizophrenia, along with data of 3180 students from Europe, the U.S., South America, and China.

European archives of psychiatry and clinical neuroscience·2024

Same author

Analysis of genetic diversity in patients with major psychiatric disorders versus healthy controls: A molecular-genetic study of 1698 subjects genotyped for 100 candidate genes (549 SNPs).

Psychiatry research·2024

Same author

Detailing the effects of polypharmacy in psychiatry: longitudinal study of 320 patients hospitalized for depression or schizophrenia.

European archives of psychiatry and clinical neuroscience·2021

Same author

Inflammatory processes linked to major depression and schizophrenic disorders and the effects of polypharmacy in psychiatry: evidence from a longitudinal study of 279 patients under therapy.

European archives of psychiatry and clinical neuroscience·2020

Same author

Predicting response to psychopharmacological treatment: survey of recent results.

Pharmacopsychiatry·2011

Same author

Onset of action under antidepressant treatment.

European psychiatry : the journal of the Association of European Psychiatrists·2009

Area of Science:

Genetics
Bioinformatics

Background:

Existing genetic maps exhibit significant variations in genome length, impacting their compatibility.
Methods for transforming and integrating diverse genetic maps are crucial for comprehensive genomic analysis.

Purpose of the Study:

To develop and validate a method for integrating disparate genetic maps with high precision.
To explore the reconstruction of sex-specific recombination data from sex-averaged genetic maps.

Main Methods:

Application of nonlinear, polynomial transformations (up to degree 5) to align six major publicly available genetic maps.
Iterative optimization of polynomial coefficients to minimize discrepancies between empirical and reconstructed marker locations.

Main Results:

Related Experiment Videos

Polynomial transformations achieved high precision, with >90% of marker locations showing differences of less than or equal to +/-0.8 cM.
Successful reconstruction of sex-specific recombination estimates from sex-averaged data was demonstrated, albeit with a slightly reduced fit.

Conclusions:

Nonlinear polynomial transformations provide a robust and precise method for integrating diverse genetic maps.
This approach facilitates the rapid incorporation of new markers into existing genetic maps, enhancing map construction methods.